Acute oral toxicity study was performed to find out the test dose according to OECD guidelines 425. Ethanolic extract of Sida rhombifolia Linn was found to be safe at a dose of 2000 mg/kg b. w. Anti-stress activity of ethanolic extract was investigated against forced swimming endurance test and chronic cold restraint stress test in rats. Two doses 200 mg/kg and 400 mg/kg b.w p.o of the extract were subjected for the evaluation of anti-stress potential. Diazepam (2 mg/kg b.w p.o) was used as a standard drug. The parameters like plasma cortisol, cholesterol and triglycerides were likely to evaluate the anti-stress activity. Both the lower (200 mg/kg) and higher dose (400 mg/kg) of Sida rhombifolia Linn extract showed dose dependent significant decrease in serum cholesterol, triglyceride and corticosterone. The results obtained were comparable with that of the standard diazepam. The present study concluded that Sida rhombifolia Linn leaves were found to be effective in antistress activity.
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